屈昌秀，博士，助理研究员
Email:changxiuq@sdu.edu.cn
【教育经历】
2013.09 - 2018.12 山东大学理学博士
2008.09 - 2012.07 山东中医药大学医学学士
【工作经历】
2023.06 -至今 山东大学基础医学院助理研究员
2019.04 - 2022.03 北京大学基础医学院 博士后
【研究方向】
长期致力于G蛋白偶联受体（GPCR）信号转导机制的研究，在PNAS, Science Advances, Nature Chemical Biology, Structure等国际知名杂志发表研究成果4篇。以共同作者在Nature, Cell, Nature Communications等顶级期刊发表研究成果11篇。解析了Arrestin作为支架蛋白与MAPK级联蛋白的互作机制（PNAS 2021, Structure 2019），揭示了GPCR别构调控SH3蛋白的信号转导规律，并探索了Arrestin的催化功能，打破了Arrestin只是“接头”蛋白的概念（Nature Chemical Biology 2018）,聚焦前列腺素受体EP2,补充了受体非传统的激活机制以及与下游Gs蛋白的新型作用模式（Science Advances 2021），为靶向GPCR调控基因表达及细胞质功能，精准抗炎、治疗癌症等提供理论依据。
【代表性论文】
Qu CX*, Mao CY*, Xiao P*, Shen QY*, Zhong YN*, Yang F*, Shen DD, Tao XN, Zhang HB,Yan X Zhao RJ, He JY, Guan Y, Zhang C, Hou GH, Zhang PJ, Hou GG, Li ZJ, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y,Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E receptor EP2 subtype. Science Advances. vol. 7,14 eabf1268. 2 Apr. 2021
Qu CX*,Park JY*,Yun MW*, He QT, Yang F, Kin K, Han D, Li R, T.M.Iverson, V V.Gurevich , Sun JP,Chung KY, Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade.Proc Natl Acad Sci U S A. 2021;118(37):e2026491118
Yang F*, Xiao P*,Qu CX*, Liu Q*, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP, Wang J,Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin,Nature Chemical Biology.2018 Sep;14(9):876-886.
Park JY*,Qu CX*, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP, Chung KY，Structural Mechanism of the Arrestin-3/JNK3 Interaction.Structure.2019 Apr 16. pii: S0969-2126(19)30124-8.
Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H,Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.Nature.2021.Jan;589(7843):620-626.
Yang, F., Guo, L., Li, Y., Wang, G., Wang, J., Zhang, C., Fang, G. X., Chen, X., Liu, L., Yan, X., Liu, Q.,Qu, C., Xu, Y., Xiao, P., Zhu, Z., Li, Z., Zhou, J., Yu, X., Gao, N., & Sun, J. P. (2021). Structure, function and pharmacology of human itch receptor complexes.Nature, 600(7887), 164–169.
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S,Qu CX, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu, Yang S, Daniel M. Rosenbaum,Sun JP, Du Y, Zhang L, Yu X, Shao Z.Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.Cell. 2021 Feb;
Yang F, Yu X, Liu C,Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY,Sun JP. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and19F-NMR.Nature Communications.08 Sep 2015 doi:10.1038/ncomms9202
Liu Q, He QT, Lyu X, Yang F, Zhu ZL, Xiao P, Yang Z, Zhang F, Yang ZY, Wang XY, Sun P, Wang Q,Qu CX, Gong Z, Lin JY, Xu Z, Song SL, Huang SM, Guo SC, Han MJ, Zhu KK, Chen X, Kahsai AW, Xiao KH, Kong W, Li FH, Ruan K, Li ZJ, Yu X, Niu XG, Jin CW, Wang J,Sun JP.DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl1H-NMR probe.Nature Communications.2020 Sep 25;11(1):4857. doi: 10.1038/s41467-020-18433-5.
Huang SM, Yang F, Cai BY, He QT, Liu Q,Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP, Wang J. Genetically Encoded Fluorescent Amino Acid for monitoring Protein Interactions through FRET.Anal Chem.2019 Dec ;91(23):14936-14942
Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF,Qu CX, Xiao P, Liu CY, Thomsen AR, Joseph Cahill T 3rd, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP, Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling,Nature Communications.2017 Feb 9; 8:14335
Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A,Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ, Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis,Proc Natl Acad Sci U S A.2017 Mar 7;114(10):2562-2567
Dolatabad MR, Guo LL, Xiao P, Zhu Z, He QT, Yang DX,Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Liu HD, Shen YM, Yu X,Sun JP, Zhang PJ, Crystal structure and catalytic activity of the PPM1K N94K mutant,J Neurochem.2019 Feb;148(4):550-560
Han, M. J., He, Q. T., Yang, M., Chen, C., Yao, Y., Liu, X., Wang, Y., Zhu, Z. L., Zhu, K. K.,Qu, C., Yang, F., Hu, C., Guo, X., Zhang, D., Chen, C., Sun, J. P., & Wang, J. (2021). Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction.Chemical science, 12(26), 9114–9123.
Huang, S. M., Xiong, M. Y., Liu, L., Mu, J., Wang, M. W., Jia, Y. L., Cai, K., Tie, L., Zhang, C., Cao, S., Wen, X., Wang, J. L., Guo, S. C., Li, Y.,Qu, C. X., He, Q. T., Cai, B. Y., Xue, C., Gan, S., Xie, Y., … Sun, J. P. . Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths.Proc Natl Acad Sci U S A, 120(30), e2216329120.
【联系方式】
地址:济南市历下区文化西路44号山东大学趵突泉校区教学6号楼
